Mikiko Sasaki was raised in Iwate prefecture, Japan. She later moved to California to attend San Francisco State University, where she concentrated on experimental filmmaking. After graduation, Mikiko worked for several productions and film organizations including KQED Public TV/ Radio, and the Sundance Institute.

Mikiko completed the M.F.A Film Directing program at the UCLA School of Film, TV & Digital Media, where she studied both narrative and documentary filmmaking. She wrote, produced and directed several films, including a short documentary Story of a Businesswoman, which screened in many film festivals across the country including Asian American International Film Festival (NYC), San Francisco Documentary FIlm Festival, and Los Angeles Asian Pacific Film Festival. 

Mikiko has since worked extensively as a documentary editor and producer. Her recent editing work includes feature films such as Mad as Hell: Rise of the Young Turks, and Aloha Buddha: The Story of Japanese Buddhism in Hawaii. She is currently directing her first feature, The Great Sasukea documentary on an enigmatic Luchador wrestler based in her hometown, Morioka.